WebMar 29, 2024 · A similar study published in Sleep Medicine demonstrated pitolisant as an effective treatment for EDS and cataplexy in children with narcolepsy. 2 Among 55 patients with narcolepsy treated with the therapy, the Pediatric Epworth Sleepiness Scale (ESS) score decreased from 19.0 to 13.5 (P <.001) and weekly cataplexy frequency increased … WebApr 28, 2024 · A newly initiated phase 3 study, dubbed INTUNE (NCT05156047), will evaluate the efficacy and safety of pitolisant (Wakix; Harmony Biosciences) in patients …
Long-term use of pitolisant to treat patients with narcolepsy
WebApr 4, 2024 · Jeffrey Dayno, MD. According to a recent announcement, the timeline for the phase 3 INTUNE study (NCT05156047) assessing Harmony’s therapy pitolisant … WebOrgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report. Gaia Pellitteri, 1, 2 Pierluigi Dolso, 1 Mariarosaria Valente, 1, 2 Gian Luigi Gigli 1– 3 1 Clinical Neurology Unit, Department of Neurosciences, Udine University Hospital, Udine, Italy; 2 Department of Medicine (DAME), University of Udine, Udine, Italy; 3 Department of … sheri wray
Pitolisant to be Evaluated in Idiopathic Hypersomnia Phase 3 Study
WebFeb 16, 2024 · Efficacy with pitolisant was consistent with study findings in adults patients with narcolepsy. For example, the Harmony I study displayed a 5.8-point mean reduction on ESS vs. placebo (−3.4) and the Harmony CTP trial had a 64% reduction in weekly cataplexy rate. 2,3. “Pitolisant is well suited for pediatric patients due to its easy once ... Webfor Pitolisant. So, an economically newer method development was undertaken in this study. 2. Materials and methods Chemicals and reagents The chemicals and reagents formic acid (analytical grade) and acetonitrile (HPLC grade) utilized for the study were purchased from local market. Pitolisant standard was obtained WebThe INTUNE study is a double-blind, placebo-controlled, randomized withdrawal study in approximately 200 IH patients which will be conducted at 60 to 80 clinical trial sites … sql server execution plan viewer